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Arthritis and auto-immunity Part 3 – theory

Arthritis Photo Credit: Handarmdoc via Flickr

Arthritis Photo Credit: Handarmdoc via Flickr

Seagate has been involved with joint pain, arthritis, and even at one point almost 20 years ago, with the local chapter of the Arthritis Foundation because of some of the products that we produce. Due to FDA regulations, and because this blog is discussing pain and this disease, there will be no discussion of treatment or specific products.

Over 40 million Americans have some sort of arthritis – osteoarthris (the most common form), rheumatoid, lupus, and fibromyalgia. There are over 100 different rheumatoid conditions and diseases. These are the most common.  The Arthritis Foundation, the largest single private supporter of arthritis research around the world, has funded over $450 million in research grants since its founding in 1948. In contrast, the U.S. government, through the National Institute of Health’s (NIH) division called the National Institute of Arthritis and Musculoskeletal and Skin Diseases has funded over $300 million in research grants each year. Despite all of this money thrown at these arthritis-related diseases, there is no cure, no treatment, and no medicine.  You could argue that we are no closer in 2016 at finding an arthritis cure than we were in 1948.

All that has been accomplished is essentially still recommending that you take aspirin and other pain killers. You could also argue that this giant bureaucracy that has developed for studying arthritis, just as has happened over the past 60 years with cancer — medical research labs, universities, drug companies, hospitals, non-profit fund raisers — that there is a huge monetary disincentive to ever curing this disease.  It is a cash cow feeding too many people.

Another theory about the cause and treatment of arthritis:

– Arthritis is the result of your body’s own auto-immune system attacking its own joints (in most cases).

– When a joint is irritated by factors such as damage, wear and tear (osteo) or genetics (rheumatoid), the cells in and around that joint secrete a substance that includes a simple peptide. That peptide, a harmless simple protein, happens to be almost identical in structure to the E. coli bacteria.

– In some people, who are predisposed to having arthritis, their bodies are unable to distinguish that this simple peptide is not an E coli infection. So their immune system makes an incorrect auto-immune response, sending some antibodies (T-cells) to the site of this concentration of these peptides, which is the area in and around the affected joint.

– The T-cells attack the harmless peptide and also attack the cells lining that joint  … further irritating them more … and causing them to release more of this same peptide in response.

– The cycle repeats itself over and over, resulting in the body’s own immune system causing the steady deterioration of that specific joint.

The solution is to find a food product that after digestion provides this identical peptide.  However, as a food product, these peptides will be traveling throughout your body rather than concentrated around the affected joint, thereby accomplishing two things:

a) The focus of the immune system will shift away from the one joint and will chase this peptide throughout the body as it circulates as a food in your bloodstream. This will give the arthritic joint a chance to calm down and repair.

b) Similar to the methodology of innoculating you to treat things like snake bites, polio, allergies and chicken pox … when you continue to expose the body to this peptide, over a period of time the immune system will eventually stop reacting, thereby ending this errant auto-immune response.

Not so friendly fish with teeth

Not so friendly fish with teeth

This guy swimming by may contain two items which could be of use for this problem.  As a diver and underwater photographer, I usually would rather take his picture than ever see him killed.  Notice the diver in the background of the photo up against a wall of the reef, trying hard to make himself invisible to this shark. He really didn’t have anything to fear. In general, most sharks found at greater depths, like this one was photographed at 110 ft., tend to be very timid, and will quickly swim away from divers if they sense you approaching too quickly. Of course there are those exceptions to this rule.

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Ruth J Kary - Have you been able to replicate this peptide/simple protein in any of your products? I’d be interested in this since I have osteoarthritis. Would like to “eat” something to eliminate this body’s response, rather than take anti-inflammatory pain relievers.
Thanks for an interesting article/theory.

Richard (Founder) - Since this is a blog about a disease, it cannot be linked to any of Seagate’s products.

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